PNU-74654 |CAS:113906-27-7 Probechem Biochemicals

Chemical Structure : PNU-74654

CAS No.: 113906-27-7

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PNU-74654 (PNU74654;PNU 74654)

货号: PC-42324Not For Human Use, Lab Use Only.

PNU-74654 (PNU74654) is a potent Wnt/beta-catenin inhibitor by disrupting Tcf/β-catenin interaction binds to β-catenin with Kd of 450 nM.

规格	价格	库存
5 mg	￥480	In stock
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

PNU-74654 (PNU74654) is a potent Wnt/beta-catenin inhibitor by disrupting Tcf/β-catenin interaction binds to β-catenin with Kd of 450 nM.
PNU-74654 significantly decreases NCI-H295 cell proliferation (96 h, IC50=69 nM), increases early and late apoptosis, decreases nuclear beta-catenin accumulation.
PNU-74654 impaires CTNNB1/beta-catenin expression and increases beta-catenin target genes.

物理化学性质&存储条件

分子量	320.34194
分子式	C19H16N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide

参考文献

1. Leal LF, et al. Oncotarget. 2015 Dec 15;6(40):43016-32.

2. Trosset JY, et al. Proteins. 2006 Jul 1;64(1):60-7.

3. Wang H, et al. Inflamm Res. 2016 Jan;65(1):61-9.

PNU-74654 (PNU74654;PNU 74654)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

PNU-74654 (PNU74654;PNU 74654)

生物&药学活性

物理化学性质&存储条件

参考文献

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