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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HSV-PNU-183792
PNU-183792

Chemical Structure : PNU-183792

CAS No.: 282536-25-8

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PNU-183792 (PNU183792)

货号: PC-23943Not For Human Use, Lab Use Only.

PNU-183792 is a potent, non-nucleoside inhibitor of herpesviruses, specifically inhibit herpesvirus polymerases with IC50 of 0.69 uM, 0.37 uM and 0.58 uM for HCMV, varicella zoster virus (VZV) and herpes simplex virus (HSV) polymerases respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PNU-183792 is a potent, non-nucleoside inhibitor of herpesviruses, specifically inhibit herpesvirus polymerases with IC50 of 0.69 uM, 0.37 uM and 0.58 uM for HCMV, varicella zoster virus (VZV) and herpes simplex virus (HSV) polymerases respectively.
PNU-183792 is inactive (IC(50) value >40 microM) against human alpha (alpha), gamma (gamma), or delta (delta) polymerases.
PNU-183792 has braod antiviral activity against both VZV (IC(50) value 0.1 microM) and HSV (IC(50) ranging from 3 to 5 microM) using plaque reduction assays.
PNU-183792 is also active (IC(50) ranging 0.1-0.7 microM) in cell culture assays against simian varicella virus (SVV), murine cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV).
PNU-183792 is also active against both GCV-resistant and CDV-resistant HCMV and against ACV-resistant HSV.
PNU-183792 is inactive against unrelated DNA and RNA viruses indicating specificity for herpesviruses.
PNU-183792 orally bioavailable and was efficacious in a model of lethal MCMV infection.

物理化学性质&存储条件

分子量 425.91
分子式 C23H24ClN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-chlorobenzyl)-1-methyl-6-(morpholinomethyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

参考文献

1. Brideau RJ, et al. Antiviral Res. 2002 Apr;54(1):19-28.

2. Knechtel ML, et al. J Med Virol. 2002 Oct;68(2):234-6.

3. Thomsen DR, et al. J Virol. 2003 Feb;77(3):1868-76.

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