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首页-抗体药物偶连体和PROTACs-ADC Cytotoxin-PNU-159682
PNU-159682

Chemical Structure : PNU-159682

CAS No.: 202350-68-3

PNU-159682 (PNU159682;PNU 159682)

货号: PC-45045Not For Human Use, Lab Use Only.

A highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity.

规格 价格 库存 数量
5 mg ¥7600 In stock
10 mg ¥12800 In stock
50 mg ¥40000 In stock

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity; a topoisomerase inhibitor and ADCs cytotoxin.

物理化学性质&存储条件

分子量 641.6192
分子式 C32H35NO13
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[(1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl]oxy]-, (8S,10S)-

参考文献

1. Quintieri L, et al. Clin Cancer Res. 2005 Feb 15;11(4):1608-17.

2. Yu SF, et al. Clin Cancer Res. 2015 Jul 15;21(14):3298-306.

3. Mazzini S, et al. Bioorg Med Chem. 2012 Dec 15;20(24):6979-88.

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