PNU-120596 | α7 nAChR PAM | Probechem Biochemicals

Chemical Structure : PNU-120596

CAS No.: 501925-31-1

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PNU-120596 (PNU120596, NSC 216666)

货号: PC-42901Not For Human Use, Lab Use Only.

PNU-120596 (NSC 216666) is a potent, selective α7 nAChR positive allosteric modulator (PAM) that enhances ACh-evoked Ca2+ flux with EC50 of 216 nM, displays no activity for α3β4, α4β2 and α9β10 nAChRs.

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50 mg	￥1280	In stock
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生物&药学活性

PNU-120596 (NSC 216666) is a potent, selective α7 nAChR positive allosteric modulator (PAM) that enhances ACh-evoked Ca2+ flux with EC50 of 216 nM, displays no activity for α3β4, α4β2 and α9β10 nAChRs.
PNU-120596 increases the channel mean open time of α7 nAChRs but has no effect on ion selectivity and little to no effect on unitary conductance.
PNU-120596 increases the frequency of ACh-evoked GABAergic postsynaptic currents in pyramidal neurons.
PNU-120596 improves the auditory gating deficit caused by amphetamine, a model of schizophrenia.

物理化学性质&存储条件

分子量	311.7209
分子式	C13H14ClN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-(5-chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-

参考文献

1. Hurst RS, et al. J Neurosci. 2005 Apr 27;25(17):4396-405.

2. Dickinson JA, et al. J Neurochem. 2007 Feb;100(4):1089-96.

3. Grønlien JH, et al. Mol Pharmacol. 2007 Sep;72(3):715-24.

PNU-120596 (PNU120596, NSC 216666)

生物&药学活性

物理化学性质&存储条件

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PNU-120596 (PNU120596, NSC 216666)

生物&药学活性

物理化学性质&存储条件

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