PM-43I |CAS: 1637532-77-4 Probechem Biochemicals

Chemical Structure : PM-43I

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PM-43I (PM-43-I)

货号: PC-35089Not For Human Use, Lab Use Only.

PM-43I is a selective inhibitor of STAT5/6 Src Homology 2 (SH2) domain, binds recombinant STAT6 and STAT5B (IC50=1.8 and 3.8 uM) with much lower affinity for STAT3 (IC50=29.9 uM).

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生物&药学活性

PM-43I is a selective inhibitor of STAT5/6 Src Homology 2 (SH2) domain, binds recombinant STAT6 and STAT5B (IC50=1.8 and 3.8 uM) with much lower affinity for STAT3 (IC50=29.9 uM).
PM-43I potently inhibits both STAT5- and STAT6-dependent allergic airway disease in mice.
PM-43I reverses preexisting allergic airway disease in mice with a minimum ED50 of 0.25 μg/kg.

物理化学性质&存储条件

分子量	777.8
分子式	C38H50F2N3O10P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,E)-(((Difluoro(4-(4-((1-(2-(methyl(phenyl)amino)-2-oxoethyl)-2-oxoazepan-3-yl)amino)-4-oxobut-2-en-2-yl)phenyl)methyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)

参考文献

1. Knight JM, et al. J Biol Chem. 2018 May 8. pii: jbc.RA117.000567.

PM-43I (PM-43-I)

生物&药学活性

物理化学性质&存储条件

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PM-43I (PM-43-I)

生物&药学活性

物理化学性质&存储条件

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