PLX7904 | B-Raf inhibitor | Probechem Biochemicals

Chemical Structure : PLX7904

CAS No.: 1393465-84-3

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PLX7904 (PLX-7904)

货号: PC-45594Not For Human Use, Lab Use Only.

PLX7904 is a potent and selective B-Raf inhibitor with IC50 of 5 nM against BRaf V600E in mutant RAS expressing cells.

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10 mg	￥1880	In stock
25 mg	￥2980	In stock
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生物&药学活性

PLX7904 is a potent and selective B-Raf inhibitor with IC50 of 5 nM against BRaf V600E in mutant RAS expressing cells.
PLX7904 inhibits the growth of A375, COLO829, COLO205 that expresses BRAFV600E with IC50 values of 0.17 uM, 0.53 uM, and 0.16 uM, respectively.
PLX7904 inhibits phosphorylation of ERK1/2 in mutant BRAF melanoma cells.

物理化学性质&存储条件

分子量	512.5317
分子式	C24H22F2N6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	Sulfamide, N'-[3-[[5-(2-cyclopropyl-5-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methyl-

参考文献

1. Zhang C, et al. Nature. 2015 Oct 22;526(7574):583-6.

PLX7904 (PLX-7904)

生物&药学活性

物理化学性质&存储条件

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PLX7904 (PLX-7904)

生物&药学活性

物理化学性质&存储条件

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