PLX5622 |CAS: 1303420-67-8 Probechem Biochemicals

Chemical Structure : PLX5622

CAS No.: 1303420-67-8

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PLX5622 (PLX 5622;PLX-5622)

货号: PC-62741Not For Human Use, Lab Use Only.

PLX5622 (PLX-5622) is a potent, selective, orally active inhibitor of CSF1R tyrosine kinase (c-Fms) activity with Ki of 5.9 nM, 60-fold less potency against KIT.

规格	价格	库存
10 mg	￥1580	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

PLX5622 (PLX-5622) is a potent, selective, orally active inhibitor of CSF1R tyrosine kinase (c-Fms) activity with Ki of 5.9 nM, 60-fold less potency against KIT.
PLX5622 dispalys least 50-fold selectivity over 4 related kinases, and over 100-fold selectivity against a panel of 230 kinases.
PLX5622 prevents microglial plaque association and improves cognition in 3xTg-AD mice, also depletes microglia and alleviates the catatonic symptoms of Cnp mutants.

物理化学性质&存储条件

分子量	395.414
分子式	C21H19F2N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine

参考文献

1. Janova H, et al. J Clin Invest. 2018 Feb 1;128(2):734-745.

2. Spangenberg E, et al. Nat Commun. 2019 Aug 21;10(1):3758.

3. Dagher NN, et al. J Neuroinflammation. 2015 Aug 1;12:139.

4. Valdearcos M, et al. Cell Rep. 2014 Dec 24;9(6):2124-38.

PLX5622 (PLX 5622;PLX-5622)

生物&药学活性

物理化学性质&存储条件

参考文献

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PLX5622 (PLX 5622;PLX-5622)

生物&药学活性

物理化学性质&存储条件

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