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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-PLTFBH
PLTFBH

Chemical Structure : PLTFBH

CAS No.:

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PLTFBH (plumbagin-triflurobenzoic hydrazide)

货号: PC-49317Not For Human Use, Lab Use Only.

PLTFBH is a cell-active small molecule inhibitor of DNAJA1, binds to and reduces protein levels of DNAJA1 and several other HSP40/J-domain proteins (JDPs), specifically reduces conformational mutp53 levels similar to PLIHZ.

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2 mg ￥1980 In stock
5 mg ￥3280 In stock
10 mg ￥5280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PLTFBH is a cell-active small molecule inhibitor of DNAJA1, binds to and reduces protein levels of DNAJA1 and several other HSP40/J-domain proteins (JDPs), specifically reduces conformational mutp53 levels similar to PLIHZ.
PLTFBH reduced the levels of multiple conformational mutp53 better than other analogs with minimal impact on wtp53 and DNA contact mutp53.
PLTFBH inhibits migratory potential of cancer cells in a manner dependent on DNAJA1 and conformational mutp53.
PLTFBH inhibited the filopodia formation induced by wt DNAJA1, with minimal impact on the filopodia formation induced by Y7A and Y8A DNAJA1 mutants.
DNAJA1, a member of heat shock protein 40 (HSP40) family, also known as J-domain proteins (JDPs), can stabilize mainly misfolded or conformational type of mutp53.

物理化学性质&存储条件

分子量 374.319
分子式 C19H13F3N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-N'-(8-hydroxy-3-methyl-4-oxonaphthalen-1(4H)-ylidene)-4-(trifluoromethyl)benzohydrazide

参考文献

1. Alalem M, et al. Cancers (Basel). 2022 Aug 29;14(17):4187.

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