PLK4 inhibitor H24

Chemical Structure : PLK4 inhibitor H24

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货号: PC-27994Not For Human Use, Lab Use Only.

PLK4 inhibitor H24 is a highly potent, selective polo-like kinase 4 (PLK4) inhibitor with IC50 of <0.1 nM, exhibits potent in vitro antiproliferative activity against the TRIM37-amplified breast cancer cell line MCF-7 (IC50=2.37 uM) and IMR-32 (IC50=1.28 uM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PLK4 inhibitor H24 is a highly potent, selective polo-like kinase 4 (PLK4) inhibitor with IC50 of <0.1 nM, exhibits potent in vitro antiproliferative activity against the TRIM37-amplified breast cancer cell line MCF-7 (IC50=2.37 uM) and IMR-32 (IC50=1.28 uM).
H24 inhibits Aurora A with an IC50 value of 151.2 nM.
H24 inhibits proliferation against IMR-32, A549, and HEK-293T cells with IC50 of 1.2-1.5 uM.
H24 inhibits the colony formation of breast cancer MCF-7 cells in a concentration-dependent manner.

物理化学性质&存储条件

分子量	497.52
分子式	C24H21F2N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-difluoro-N-(2-((4-morpholinophenyl)amino)quinazolin-7-yl)benzenesulfonamide

参考文献

1. Wenqiang Sun, et al. Biomedicines. 2026 Aug 12;14(8):1811.