PLK1 inhibitor B31

Chemical Structure : PLK1 inhibitor B31

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货号: PC-24019Not For Human Use, Lab Use Only.

PLK1 inhibitor B31 is a potent, highly selective and orally active inhibitor of polo-like kinase 1 (PLK1) with IC50 of 20 nM, >200-fold selective over PLK2/PLK3.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

PLK1 inhibitor B31 is a potent, highly selective and orally active inhibitor of polo-like kinase 1 (PLK1) with IC50 of 20 nM, >200-fold selective over PLK2/PLK3.

物理化学性质&存储条件

分子量	558.12
分子式	C28H40ClN7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-((3-Chloro-2-(3-hydroxypropoxy)-5-(4-methylpiperazin-1-yl)phenyl)amino)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one

参考文献

1. Nie J, et al. J Med Chem. 2025 Feb 18. doi: 10.1021/acs.jmedchem.4c02422.