PLIHZ | DNAJA1 inhibitor | Probechem Biochemicals

Chemical Structure : PLIHZ

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PLIHZ (Plumbagin-isonicotiyl hydrazide)

货号: PC-49316Not For Human Use, Lab Use Only.

PLIHZ is a small molecule inhibitor of DNAJA1 derived from the natural compound plumbagin, binds to J domain of DNAJA1 and efficiently reduces the levels of DNAJA1 and several conformational mutp53 with minimal impact on DNA contact mutp53 and wild-type p53 (wtp53).

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生物&药学活性

PLIHZ is a small molecule inhibitor of DNAJA1 derived from the natural compound plumbagin, binds to J domain of DNAJA1 and efficiently reduces the levels of DNAJA1 and several conformational mutp53 with minimal impact on DNA contact mutp53 and wild-type p53 (wtp53).
Cells harboring conformational mutp53 exhibited lower 24h-IC50 values for PLIHZ, compared to cells with DNA contact mutp53, p53 null, or wtp53, regardless of cancer cells or non-tumor cells.
DNAJA1, a member of heat shock protein 40 (HSP40) family, also known as J-domain proteins (JDPs), can stabilize mainly misfolded or conformational type of mutp53.

物理化学性质&存储条件

分子量	307.309
分子式	C17H13N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N'-(8-hydroxy-3-methyl-4-oxonaphthalen-1(4H)-ylidene)isonicotinohydrazide

参考文献

1. Alalem M, et al. Cancers (Basel). 2022 Aug 29;14(17):4187.

PLIHZ (Plumbagin-isonicotiyl hydrazide)

生物&药学活性

物理化学性质&存储条件

参考文献

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PLIHZ (Plumbagin-isonicotiyl hydrazide)

生物&药学活性

物理化学性质&存储条件

参考文献

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