PKRA7 | PK2 antagonist | Probechem Biochemicals

Chemical Structure : PKRA7

CAS No.: 1233926-87-8

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PKRA7 (PKRA83)

货号: PC-23950Not For Human Use, Lab Use Only.

PKRA7 (PKRA83) is a potent polypeptide chemokine PK2 (Bv8, PROK2) antagonist, potently inhibit PK2 receptors with IC50 of 5.0 and 8.2 nM for PKR1 and PKR2, respectively.

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10 mg	￥2180	In stock
25 mg	￥3880	In stock
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生物&药学活性

PKRA7 (PKRA83) is a potent polypeptide chemokine PK2 (Bv8, PROK2) antagonist, potently inhibit PK2 receptors with IC50 of 5.0 and 8.2 nM for PKR1 and PKR2, respectively.
PKRA7 blocks endothelial cell branching, myeloid cell migration, and PK2-induced expression of specific chemokine/chemokine receptors.
PKRA7 decreases subcutaneous and intracranial glioblastoma xenograft tumor growth.
PKRA7 enhances the efficacy of chemotherapeutic drugs to reduce glioblastoma and pancreatic xenograft tumor growth.

物理化学性质&存储条件

分子量	505.03
分子式	C27H34ClFN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Pyrrolidinecarboxamide, N-[(9-chloro-3,4-dihydro-2H-1,5-benzodioxepin-7-yl)methyl]-1-[(4-fluoro-3-methoxyphenyl)methyl]-N-(2-methylpropyl)-, (3R)-

参考文献

1. Valerie F Curtis, et al. PLoS One. 2013;8(1):e54916.

PKRA7 (PKRA83)

生物&药学活性

物理化学性质&存储条件

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PKRA7 (PKRA83)

生物&药学活性

物理化学性质&存储条件

参考文献

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