PKRA7 (PKRA83)

Chemical Structure : PKRA7

CAS No.: 1233926-87-8

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货号: PC-23950Not For Human Use, Lab Use Only.

PKRA7 (PKRA83) is a potent prokineticin receptor 2 (PKR2, PROK2, PK2) antagonist, potently inhibits PK2 receptors with IC50 of 5.0 and 8.2 nM for PKR1 and PKR2, respectively.

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10 mg	￥2180	In stock
25 mg	￥3880	In stock
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生物&药学活性

PKRA7 (PKRA83) is a potent prokineticin receptor 2 (PKR2, PROK2, PK2) antagonist, potently inhibits PK2 receptors with IC50 of 5.0 and 8.2 nM for PKR1 and PKR2, respectively.
PKRA7 blocks endothelial cell branching, myeloid cell migration, and PK2-induced expression of specific chemokine/chemokine receptors.
PKRA7 decreases subcutaneous and intracranial glioblastoma xenograft tumor growth.
PKRA7 enhances the efficacy of chemotherapeutic drugs to reduce glioblastoma and pancreatic xenograft tumor growth.

物理化学性质&存储条件

分子量	505.03
分子式	C27H34ClFN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Pyrrolidinecarboxamide, N-[(9-chloro-3,4-dihydro-2H-1,5-benzodioxepin-7-yl)methyl]-1-[(4-fluoro-3-methoxyphenyl)methyl]-N-(2-methylpropyl)-, (3R)-

参考文献

1. Valerie F Curtis, et al. PLoS One. 2013;8(1):e54916.

PKRA7 (PKRA83)

生物&药学活性

物理化学性质&存储条件

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PKRA7 (PKRA83)

生物&药学活性

物理化学性质&存储条件

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