PKCα/β inhibitor Cmpd 1 | PKCα/β inhibitor | Probechem Biochemicals

Chemical Structure : PKCα/β inhibitor Cmpd 1

CAS No.: 1046787-18-1

加入收藏

PKCα/β inhibitor Cmpd 1 (PKC-IN-1)

货号: PC-63224Not For Human Use, Lab Use Only.

PKCα/β inhibitor Cmpd 1 is a potent and selective inhibitor of Protein Kinase C (PKC) family members PKCα and PKCβ with IC50 of 2 nM and 11 nM, respectively.

规格	价格	库存
5 mg	￥2980	In stock
10 mg	￥4780	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

PKCα/β inhibitor Cmpd 1 is a potent and selective inhibitor of Protein Kinase C (PKC) family members PKCα and PKCβ with IC50 of 2 nM and 11 nM, respectively.

PKCα/β inhibitor Cmpd 1 shows moderate activity against PKCθ (IC50 28 nM) and PKCγ (IC50 96 nM), >40-fold selectivity over other PKC family members.

PKCα/β inhibitor Cmpd 1inhibits production of IL-8 in response to the DAG mimic and PKC activator phorbol 12-myristate 13-acetate (PMA) with IC50 of 26 nM.

PKCα/β inhibitor Cmpd 1 inhibits PKC in vitro in PKC activity assays using glomerular source material.

PKCα/β inhibitor Cmpd 1 (100 mpk/day) decreases food consumption and causes weight loss in ZSF1 obese animals.

物理化学性质&存储条件

分子量	500.623
分子式	C25H37FN8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((2S,5R)-2,5-dimethyl-4-((tetrahydro-2H-pyran-4-yl)methyl)piperazin-1-yl)(3-((5-fluoro-2-methylpyrimidin-4-yl)amino)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl)methanone

参考文献

1. Wang J, et al. Sci Rep. 2023 Oct 7;13(1):16919.
2. Patent WO2021113766 (Cmpd A).

PKCα/β inhibitor Cmpd 1 (PKC-IN-1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PKCα/β inhibitor Cmpd 1 (PKC-IN-1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.