PKCiota-IN-51 |CAS: 2230052-97-6 Probechem Biochemicals

Chemical Structure : PKCiota-IN-51

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PKCiota-IN-51 (PKC-ι inhibitor 51)

货号: PC-63488Not For Human Use, Lab Use Only.

PKCiota-IN-51 is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.7 nM, >15-fold selectivity over PKC-α and PKC-β.

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生物&药学活性

PKC-ι inhibitor 51 (PKCiota-IN-51) is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.7 nM, >15-fold selectivity over PKC-α and PKC-β.
PKC-ι inhibitor 51 inhibits PKC-ι on the phosphorylation of substrate ECT2 in HCCLM3 cells with IC50 of 3.3 uM.

物理化学性质&存储条件

分子量	427.483
分子式	C25H22FN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(5-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-a]pyridin-3-yl)-3-(fluoromethyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

参考文献

1. Kwiatkowski J, et al. J Med Chem. 2018 May 4. doi: 10.1021/acs.jmedchem.8b00060.

PKCiota-IN-51 (PKC-ι inhibitor 51)

生物&药学活性

物理化学性质&存储条件

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PKCiota-IN-51 (PKC-ι inhibitor 51)

生物&药学活性

物理化学性质&存储条件

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