PKCiota-IN-49 |CAS: 2230055-52-2 Probechem Biochemicals

Chemical Structure : PKCiota-IN-49

CAS No.: 2230055-52-2

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PKCiota-IN-49 (PKCiota inhibitor 49)

货号: PC-63489Not For Human Use, Lab Use Only.

PKCiota-IN-49 (PKCiota inhibitor 49) is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.8 nM, >20-fold selectivity over PKC-α (IC50=71 nM) and PKC-β (IC50=350 nM).

规格	价格	库存
5 mg	￥2980	In stock
10 mg	￥4580	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

PKCiota-IN-49 (PKCiota inhibitor 49) is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.8 nM, >20-fold selectivity over PKC-α (IC50=71 nM) and PKC-β (IC50=350 nM).
PKCiota-IN-49 inhibits PKC-ι on the phosphorylation of substrate ECT2 in HCCLM3 cells with IC50 of 3.0 uM.

物理化学性质&存储条件

分子量	395.466
分子式	C24H21N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(5-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-a]pyridin-3-yl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

参考文献

1. Kwiatkowski J, et al. J Med Chem. 2018 May 4. doi: 10.1021/acs.jmedchem.8b00060.

PKCiota-IN-49 (PKCiota inhibitor 49)

生物&药学活性

物理化学性质&存储条件

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PKCiota-IN-49 (PKCiota inhibitor 49)

生物&药学活性

物理化学性质&存储条件

参考文献

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