PKC agonist C-233

Chemical Structure : PKC agonist C-233

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货号: PC-23919Not For Human Use, Lab Use Only.

PKC agonist C-233 is a selective PKC-ε agonist with EC50 of 240 nM, has 196-fold selectivity over PKC-δ and 5-6 fold over PKC-η and PKC-θ.

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生物&药学活性

PKC agonist C-233 is a selective PKC-ε agonist with EC50 of 240 nM, has 196-fold selectivity over PKC-δ and 5-6 fold over PKC-η and PKC-θ.
induced cytokines associated with PKC activation, consistent with expression of PKC-ε in T cells.
C-233 shows improved potency for T cells in vitro and induces HIV activation ex vivo.
C-233 strongly activated CD69 expression (EC50 = 99 nM) in CD4+ T cells isolated from people with HIV receiving ART.
C-233 shows greater activity in T cells than in platelets, and the ability to activate HIV RNA and p24 expression.

物理化学性质&存储条件

分子量	475.54
分子式	C31H25NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-(2-(hydroxymethyl)-4-phenyl-2,3-dihydrofuro[2,3-b]pyridin-2-yl)methyl 4-(p-tolylethynyl)benzoate

参考文献

1. Irrinki AM, et al. PLoS Pathog. 2025 Feb 6;21(2):e1012874.

PKC agonist C-233

生物&药学活性

物理化学性质&存储条件

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PKC agonist C-233

生物&药学活性

物理化学性质&存储条件

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