PKA inhibitor H89 | PKA inhibitor | Probechem Biochemicals

Chemical Structure : PKA inhibitor H89

CAS No.: 130964-39-5

加入收藏

PKA inhibitor H89 (H-89 dihydrochloride)

货号: PC-20821Not For Human Use, Lab Use Only.

PKA inhibitor H89 (H-89 dihydrochloride) is a potent, selective cAMP-dependent protein kinase A (PKA) inhibitor with IC50 of 48 nM, weakly inhibits PKG, PKC, casein kinases.

规格	价格	库存
10 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1480	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

PKA inhibitor H89 (H-89 dihydrochloride) is a potent, selective cAMP-dependent protein kinase A (PKA) inhibitor with IC50 of 48 nM, weakly inhibits PKG, PKC, casein kinases.
PKA inhibitor H89 causes a dose-dependent inhibition of the forskolin-induced protein phosphorylation, with no decrease in intracellular cyclic AMP levels in PC12D cells.
PKA inhibitor H89 significantly inhibits the forskolin-induced neurite outgrowth from PC12D cells.
PKA inhibitor H89 (30 μM) inhibited significantly cAMP-dependent histone IIb phosphorylation activity in cell lysates but did not affect other protein phosphorylation activity.
PKA inhibitor H89 significantly increases seizure latency and threshold in PTZ-treated animals.

物理化学性质&存储条件

分子量	519.28
分子式	C20H22BrCl2N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(2-((3-(4-bromophenyl)allyl)amino)ethyl)isoquinoline-5-sulfonamide dihydrochloride

参考文献

1. Hansen SH, et al. J Cell Biol. 1994 Aug;126(3):677-87.

2. Chijiwa T, et al. J Biol Chem. 1990 Mar 25;265(9):5267-72.

3. Hosseini-Zare MS, et al. Eur J Pharmacol. 2011 Nov 30;670(2-3):464-70.

PKA inhibitor H89 (H-89 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PKA inhibitor H89 (H-89 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.