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首页-小分子抑制剂&激动剂-Apoptosis-MDM2-p53-PK11000
PK11000

Chemical Structure : PK11000

CAS No.: 38275-34-2

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PK11000 (PK-11000)

货号: PC-25969Not For Human Use, Lab Use Only.

PK11000 is a small molecule allosteric disruptor Y220C and Y220C p53 reactivator, reactivates p53 native function in Y220C mutant present tumors.

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25 mg ￥880 In stock
50 mg ￥1280 In stock
100 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PK11000 is a small molecule allosteric disruptor Y220C and Y220C p53 reactivator, reactivates p53 native function in Y220C mutant present tumors.
PK11000 rescues Y220C mutant p53 DBD by recapitulating WT dynamics and hydrogen-bonding network.
PK11000 restore stability and reinstate activity both in vitro and in vivo in rodent models.

物理化学性质&存储条件

分子量 236.63
分子式 C6H5ClN2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid

参考文献

1. Han ISM, et al. ACS Omega. 2022 Jan 13;7(3):2831-2841.

2. Han ISM, et al. ACS Omega. 2024 Apr 22;9(18):19837-19847.

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