PITPNM3 inhibitor C8018-7840 is a selective small molecular inhibitor of oncogenic membrane-associated phosphatidylinositol transfer protein 3 (PITPNM3) with binding KD of 500 nM, inhibits CCL18-PITPNM3 signaling mediated cell migration and invasion.
PITPNM3 inhibitor C8018-7840 is a selective small molecular inhibitor of oncogenic membrane-associated phosphatidylinositol transfer protein 3 (PITPNM3) with binding KD of 500 nM, inhibits CCL18-PITPNM3 signaling mediated cell migration and invasion.
C8018-7840 inhibited PITPNM3-induced cell migration as well as invasion in a concentration-dependent manner in MDA-MB-231 and MCF-7 cells, notably decreased CCL18-PITPNM3 induced vimentin and recovered CDH1 expression.
C8018-7840 loaded nanoparticles (NP-C8018- 7840) with its volume ratio to PEG-PLGA at 1:20, showed favorable pharmacokinetics for in vivo use.
C8018-7840 significantly repress metastasis of breast cancer in mouse xenograft models and organoid models.
