PIT-1 | PIP3 antagonist | Probechem Biochemicals

Chemical Structure : PIT-1

CAS No.: 53501-41-0

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PIT-1 (PIP3 antagonist)

货号: PC-62042Not For Human Use, Lab Use Only.

PIT-1 is a specific PIP3 antagonist that disrupts PIP3/Akt PH domain binding with IC50 of 30 uM, Kd of 43.2 uM.

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50 mg	￥1080	In stock
100 mg	￥1680	In stock
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生物&药学活性

PIT-1 is a specific PIP3 antagonist that disrupts PIP3/Akt PH domain binding with IC50 of 30 uM, Kd of 43.2 uM.
PIT-1 inhibits interactions of a number of PIP3-binding PH domains, including those of Akt and PDK1, without affecting several PIP2-selective PH domains.
PIT-1 suppresses the PI3K-PDK1-Akt pathway and triggers metabolic stress and apoptosis.

物理化学性质&存储条件

分子量	351.76
分子式	C14H10ClN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-benzamide

参考文献

1. Miao B, et al. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31.

2. Manna P, et al. Cell Physiol Biochem. 2014;33(4):1197-204.

3. Miao B, et al. Oncogene. 2012 Sep 27;31(39):4317-32.

PIT-1 (PIP3 antagonist)

生物&药学活性

物理化学性质&存储条件

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PIT-1 (PIP3 antagonist)

生物&药学活性

物理化学性质&存储条件

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