PIP4K-IN-a131 | PIP4K inhibitor | Probechem Biochemicals

Chemical Structure : PIP4K-IN-a131

CAS No.: 2055405-95-1

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PIP4K-IN-a131 (PIP4K inhibitor a131)

货号: PC-72464Not For Human Use, Lab Use Only.

PIP4K-IN-a131 (PIP4K inhibitor a131) is a PIP4K lipid kinase inhibitor with IC50 of 1.9 uM (PI5P4Kα), selectively kills cancer cells, while protecting normal cells.

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5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5580	In stock
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100 mg		Get quote

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生物&药学活性

PIP4K-IN-a131 (PIP4K inhibitor a131) is a PIP4K lipid kinase inhibitor with IC50 of 1.9 uM (PI5P4Kα), selectively kills cancer cells, while protecting normal cells.
PIP4K-IN-a131 inhibits the kinase activity of purified PIP4K2A in vitro as well as PIP4Ks activity with IC50 of 1.9 uM and 0.6 uM, respectively.
Ras activation overrides a131-induced PIK3IP1 upregulation and activates the PI3K/Akt/mTOR pathway.

物理化学性质&存储条件

分子量	295.3
分子式	C20H13N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-2-(1H-indol-3-yl)-3-isoquinolin-5-ylprop-2-enenitrile

参考文献

1. Mayumi Kitagawa, et al. Nat Commun. 2017 Dec 19;8(1):2200.

PIP4K-IN-a131 (PIP4K inhibitor a131)

生物&药学活性

物理化学性质&存储条件

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PIP4K-IN-a131 (PIP4K inhibitor a131)

生物&药学活性

物理化学性质&存储条件

参考文献

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