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首页-小分子抑制剂&激动剂-Others-Other Targets-PIP-199
PIP-199

Chemical Structure : PIP-199

CAS No.: 622795-76-0

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PIP-199 (PIP 199)

货号: PC-21028Not For Human Use, Lab Use Only.

PIP-199 is a small-molecule inhibitor of the Fanconi anemia complementation group M-RecQ-mediated genome instability protein (FANCM-RMI) protein-protein interaction, inhibits RMI core complex with Kd of 3.4 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PIP-199 is a small-molecule inhibitor of the Fanconi anemia complementation group M-RecQ-mediated genome instability protein (FANCM-RMI) protein-protein interaction, inhibits RMI core complex with Kd of 3.4 uM.
PIP-199 exhibits selective inhibition of the RMI core complex/MM2 complex formation with IC50 of 36 uM.
PIP-199 similarly phenocopies FANCM depletion.

物理化学性质&存储条件

分子量 456.55
分子式 C27H28N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(N1CCN(C(C2=C(C3=CC=CC=C3)N(O)C4=C2C=CC=C4)C5=NC=CC=C5)CC1)OCC

参考文献

1. Andrew F Voter, et al. J Biomol Screen. 2016 Jul;21(6):626-33.

2. Xinyi Wu, et al. J Med Chem. 2023 Aug 9. doi: 10.1021/acs.jmedchem.3c00674.

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