PIN1 inhibitor VS10 |CAS:920849-78-1 Probechem Biochemicals

Chemical Structure : PIN1 inhibitor VS10

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PIN1 inhibitor VS10 (VS10)

货号: PC-36053Not For Human Use, Lab Use Only.

PIN1 inhibitor VS10 is a novel potent small molecule inhibitor of PIN1 (peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1), inhibits human PIN1 isomerization with IC50 of 13.4 uM.

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生物&药学活性

PIN1 inhibitor VS10 is a novel potent small molecule inhibitor of PIN1 (peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1), inhibits human PIN1 isomerization with IC50 of 13.4 uM.
VS10 displays >2-fold more potency than ATRA; reduces cancer cell viability of ovarian cancer cell lines with IC50 of 53.9-76.4 uM.
VS10 targets PIN1 to the proteasome, and induces PIN1 protein degradation in NIH3T3 fibroblasts, also shows inhibitory effects on PIN1 target proteins (cyclin D1, pSer473-Akt and β-catenin) in the OVCAR3 cell line.

物理化学性质&存储条件

分子量	377.414
分子式	C21H15NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-methylbenzofuran-2-carboxamido)-5-phenylthiophene-2-carboxylic acid

参考文献

1. Russo Spena C, et al. J Cell Physiol. 2019 Jan 29. doi: 10.1002/jcp.28224.

PIN1 inhibitor VS10 (VS10)

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PIN1 inhibitor VS10 (VS10)

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