PIM-447 |CAS:1210608-43-7 Probechem Biochemicals

Chemical Structure : PIM-447

CAS No.: 1210608-43-7

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PIM-447 (LGH-447;PIM447;LGH447)

货号: PC-45605Not For Human Use, Lab Use Only.

PIM-447 (LGH-447) is a highly potent and selective inhibitor of pan-Pim with IC50s of 6/18/9 pM for Pim/1/2/3 respectively.

规格	价格	库存
1 mg	￥1280	In stock
2 mg	￥1780	In stock
5 mg	￥2780	In stock
10 mg		Get quote
25 mg		Get quote

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生物&药学活性

PIM-447 (LGH-447) is a highly potent and selective inhibitor of pan-Pim with IC50s of 6/18/9 pM for Pim/1/2/3 respectively.
PIM-447 (LGH-447) induces apoptosis by a decrease in phospho-Bad Ser112 and c-Myc levels and the inhibition of mTORC1 pathway.
PIM-447 (LGH-447) significantly reduces the tumor burden and prevents tumor-associated bone loss in a murine model of human myeloma.

物理化学性质&存储条件

分子量	440.4608
分子式	C24H23F3N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Pyridinecarboxamide, N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-

参考文献

1. Burger MT, et al. J Med Chem. 2015 Nov 12;58(21):8373-86.

2. Paíno T, et al. Clin Cancer Res. 2017 Jan 1;23(1):225-238.

3. Peters TL, et al. Oncotarget. 2016 Sep 27;7(39):63362-63373.

PIM-447 (LGH-447;PIM447;LGH447)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

PIM-447 (LGH-447;PIM447;LGH447)

生物&药学活性

物理化学性质&存储条件

参考文献

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