欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PIKfyve-PIKfyve inhibitor WX8
PIKfyve inhibitor WX8

Chemical Structure : PIKfyve inhibitor WX8

CAS No.: 1164477-46-6

加入收藏

PIKfyve inhibitor WX8 (WX8)

货号: PC-47004Not For Human Use, Lab Use Only.

WX8 is a specific inhibitor of PIKfyve, induces accumulation of cytoplasmic vacuoles on osteosarcoma U2OS cells with EC50 of 10 nM.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    WX8 is a specific inhibitor of PIKfyve, induces accumulation of cytoplasmic vacuoles on osteosarcoma U2OS cells with EC50 of 10 nM.
    WX8 induced accumulation of 2 autophagosome biomarkers, the phosphatidylethanolamine conjugate (LC3-II) of MAP1LC3A protein (LC3-I), and the SQSTM1/p62 ubiquitin-binding protein (sequestosome 1)
    WX8 inhibited U2OScell proliferation and viability with IC50 of 0.2 and 0.35 uM, respectively.
    WX8 impaired lysosomal trafficking, did not impair lysosomal acidity.
    WX8 prevented heterotypic fusion of lysosomes with autophagosomes.
    Pretreatment of eliminate pluripotent embryonal carcinoma cells (ECCs) with WX8 suppressed their ability to form teratocarcinomas in mice, selectively eliminated pluripotent cells in mice harboring teratocarcinoma xenografts.

    物理化学性质&存储条件

    分子量 414.473
    分子式 C22H22N8O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (Z)-4-(2-((3H-indol-3-ylidene)methyl)hydrazinyl)-6-morpholino-N-phenyl-1,3,5-triazin-2-amine

    参考文献

    1. Gaurav Sharma, et al. Autophagy. 2019 Oct;15(10):1694-1718.

    2. Arup R Chakraborty, et al. Stem Cell Reports. 2022 Feb 8;17(2):397-412.

    备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    联系我们 sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    询单

    • *产品名称:
    • *姓名:
    • *邮箱:
    • *公司名称:
    • *询单数量:
    • *国籍:
    • 询单信息: