PIKfyve inhibitor 40

Chemical Structure : PIKfyve inhibitor 40

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货号: PC-23927Not For Human Use, Lab Use Only.

PIKfyve inhibitor 40 is a potent, selective, second-generation inhibitor of PIKfyve with enzyme IC50 of 0.6 nM, and 0.35 nM in NanoBRET assays.

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250 mg		Get quote

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生物&药学活性

PIKfyve inhibitor 40 is a potent, selective, second-generation inhibitor of PIKfyve with enzyme IC50 of 0.6 nM, and 0.35 nM in NanoBRET assays.
PIKfyve inhibitor 40 demonstrates weak binding (IC50 > 1700 nM) to all kinases except for PIP4K2C (IC50 = 200 nM), has a > 500-fold in-cell selectivity for PIKfyve versus the remainder of kinases in the 240-member NanoBRET panel.

物理化学性质&存储条件

分子量	294.38
分子式	C16H14N4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(5-(3-(Methylthio)prop-1-yn-1-yl)-1H-indol-3-yl)pyrimidin-2-amine

参考文献

1. Min SM, et al. J Med Chem. 2025 Jan 22. doi: 10.1021/acs.jmedchem.4c02531.