PIK-93 |CAS:593960-11-3 Probechem Biochemicals

Chemical Structure : PIK-93

CAS No.: 593960-11-3

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PIK-93 (PIK 93;PIK93)

货号: PC-42861Not For Human Use, Lab Use Only.

PIK-93 is a potent, synthetic PI4K inhibitor with IC50 of 19 nM (PI4KIIIβ), also inhibits PI3Kγ and PI3Kα with IC50 of 16 nM and 39 nM, respectively.

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10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg		Get quote

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生物&药学活性

PIK-93 is a potent, synthetic PI4K inhibitor with IC50 of 19 nM (PI4KIIIβ), also inhibits PI3Kγ and PI3Kα with IC50 of 16 nM and 39 nM, respectively.
PIK-93 also inhibits other PI3Ks, including PI3Kα, β, and δ, with IC50 values of 39 nM, 0.59 uM, and 0.12 uM, shows no inhibitory effect against a panel of other kinases.
PIK-93 significantly inhibits the conversion of [3H]serine-labeled endogenous ceramide to sphingomyelin, reduces carbachol-induced translocation of TRPC6 to the plasma membrane and net Ca2+ entry in T6.11 cells at 300 nM.
PIK-93 also demonstrates anti-enterovirus effects by inhibition of both poliovirus and HCV replication with EC50 of 0.14 uM and 1.9 uM, respectively.

物理化学性质&存储条件

分子量	389.8775
分子式	C14H16ClN3O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetamide, N-[5-[4-chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]-

参考文献

1. Knight ZA, et al. Cell. 2006 May 19;125(4):733-47.

2. Monet M, et al. J Biol Chem. 2012 May 18;287(21):17672-81.

3. Tóth B, et al. J Biol Chem. 2006 Nov 24;281(47):36369-77.

4. Arita M, et al. J Virol. 2011 Mar;85(5):2364-72.

PIK-93 (PIK 93;PIK93)

生物&药学活性

物理化学性质&存储条件

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PIK-93 (PIK 93;PIK93)

生物&药学活性

物理化学性质&存储条件

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