PIK-90 |CAS:677338-12-4 Probechem Biochemicals

Chemical Structure : PIK-90

CAS No.: 677338-12-4

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PIK-90 (PIK90;PIK 90)

货号: PC-42844Not For Human Use, Lab Use Only.

PIK-90 is a potent DNA-PK and PI3K inhibitor that inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively.

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25 mg	￥1480	In stock
50 mg	￥2380	In stock
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生物&药学活性

PIK-90 is a potent DNA-PK and PI3K inhibitor that inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively.
PIK-90 inhibits phosphorylation of Akt and S6, blocks the antiapoptotic protein Survivin and driving cell death in malignant glioma the clinical CDK1/2 inhibitor cooperated with roscovitine.

物理化学性质&存储条件

分子量	351.3593
分子式	C18H17N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: < 1 mg/mL
Chemical Name/SMILES	3-Pyridinecarboxamide, N-(2,3-dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-

参考文献

1. Fan QW, et al. Cancer Res. 2007 Sep 1;67(17):7960-5.

2. Niedermeier M, et al. Blood. 2009 May 28;113(22):5549-57.

3. Knight ZA, et al. Cell. 2006 May 19;125(4):733-47.

4. Cheng CK, et al. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12722-7.

PIK-90 (PIK90;PIK 90)

生物&药学活性

物理化学性质&存储条件

参考文献

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PIK-90 (PIK90;PIK 90)

生物&药学活性

物理化学性质&存储条件

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