PI3Kβ inhibitor (P)-14

首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PI3K-PI3Kβ inhibitor (P)-14

Chemical Structure : PI3Kβ inhibitor (P)-14

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货号: PC-20468Not For Human Use, Lab Use Only.

PI3Kβ inhibitor (P)-14 is a potent, highly selective and orally bioavailable PI3Kβ inhibitor with IC50 of 2 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PI3Kβ inhibitor (P)-14 is a potent, highly selective and orally bioavailable PI3Kβ inhibitor with IC50 of 2 nM.
PI3Kβ inhibitor (P)-14 inhibits the phosphorylation of AKT (AKT1 ser473) in PTEN-deficient tumor cell lines with EC50 of 5-30 nM.

物理化学性质&存储条件

分子量	464.44
分子式	C25H14F2N8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[1-(5,8-Difluoro-4-quinolinyl)-2-methyl-4-(1H-1,2,4-triazol-5-yl)-1H-benzimidazol-6-yl]-2-pyridinecarbonitrile

参考文献

1. Stephane Perreault, et al. ACS Med Chem Lett. 2020 Apr 13;11(6):1236-1243.

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