PI3Kα-IN-4h |CAS:2100855-80-7 Probechem Biochemicals

Chemical Structure : PI3Kα-IN-4h

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PI3Kα-IN-4h

货号: PC-62843Not For Human Use, Lab Use Only.

PI3Kα-IN-4h is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively.

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生物&药学活性

PI3Kα-IN-4h is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively.
PI3Kα-IN-4h displays good selectivity for PI3Kα.
PI3Kα-IN-4h demonstrates cytotoxicity in MCF7 cells, reasonable toxicity in MDA-MB-468 cells, good therapeutic index compared to normal skin fibroblasts, and acceptable in vitro ADME properties.

物理化学性质&存储条件

分子量	483.532
分子式	C26H25N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(3-(4-(4-morpholinopyrido[3,2-d]pyrimidin-2-yl)phenyl)ureido)phenyl)acetamide

参考文献

1. Al-Ashmawy AAK, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3117-3122.

PI3Kα-IN-4h

生物&药学活性

物理化学性质&存储条件

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PI3Kα-IN-4h

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