PI3K-IN-8q |CAS:1280204-67-2 Probechem Biochemicals

Chemical Structure : PI3K-IN-8q

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PI3K-IN-8q (p110α/p110δ inhibitor)

货号: PC-62830Not For Human Use, Lab Use Only.

PI3K-IN-8q is a potent, selective dual p110α/p110δ inhibitor with Ki app of 3.3/8.36 nM respectively.

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生物&药学活性

PI3K-IN-8q is a potent, selective dual p110α/p110δ inhibitor with Ki app of 3.3/8.36 nM respectively.
PI3K-IN-8q exhibits high selectivity over p110α and p110β (Ki>490 nM); inhibits p-Akt with EC50 of 50 nM, and p110α with IC50 of 0.5 nM.
PI3K-IN-8q has promising in vivo PK data; orally bioavailable.

物理化学性质&存储条件

分子量	446.49
分子式	C23H23FN8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2-(4-fluorophenyl)-9-morpholino-1,2,3,4-tetrahydropyrido[3',4':4,5]imidazo[1,2-a]pyrazin-7-yl)pyrimidin-2-amine

参考文献

1. Martínez González S, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2536-2543.

PI3K-IN-8q (p110α/p110δ inhibitor)

生物&药学活性

物理化学性质&存储条件

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PI3K-IN-8q (p110α/p110δ inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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