PI3Kβ/δ inhibitor 20a |CAS:1842380-77-1 Probechem Biochemicals

Chemical Structure : PI3Kβ/δ inhibitor 20a

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PI3Kβ/δ inhibitor 20a (PI3K-IN-6)

货号: PC-61135Not For Human Use, Lab Use Only.

PI3Kβ/δ inhibitor 20a is a potent, highly selective PI3Kβ/δ inhibitor with IC50 of 7.8/5.3 nM respectively, with liitle to no activity on PI3Kα/γ (IC50=850/>10,000 nM).

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生物&药学活性

PI3Kβ/δ inhibitor 20a is a potent, highly selective PI3Kβ/δ inhibitor with IC50 of 7.8/5.3 nM respectively, with liitle to no activity on PI3Kα/γ (IC50=850/>10,000 nM).
PI3Kβ/δ inhibitor 20a inhibits the phosphorylation of AKT1 Ser473 in PI3K-dependent cell lines with EC50 of 3.4-7.3 nM, inhibits AKT Ser473 phosphorylation and cell viability of LNCaP tumor cells with EC50 of 7.3 nM and GI50 of 38 nM.
PI3Kβ/δ inhibitor 20a demonstrates efficacy in human PTEN-deficient LNCaP prostate carcinoma xenograft tumor model.

物理化学性质&存储条件

分子量	450.259
分子式	C17H14Cl2FN9O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one

参考文献

1. Perreault S, et al. J Med Chem. 2017 Feb 23;60(4):1555-1567.

PI3Kβ/δ inhibitor 20a (PI3K-IN-6)

生物&药学活性

物理化学性质&存储条件

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PI3Kβ/δ inhibitor 20a (PI3K-IN-6)

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物理化学性质&存储条件

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