PI3Kα H1047R inhibitor 17

Chemical Structure : PI3Kα H1047R inhibitor 17

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货号: PC-21947Not For Human Use, Lab Use Only.

PI3Kα H1047R inhibitor 17 is a potent, selective H1047R PI3Kα mutant inhibitor with IC50 of 1 nM (inhibition of pAKT formation), without effect on PI3Kα WT.

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

PI3Kα H1047R inhibitor 17 is a potent, selective H1047R PI3Kα mutant inhibitor with IC50 of 1 nM (inhibition of pAKT formation), without effect on PI3Kα WT.
PI3Kα H1047R inhibitor 17 exhibits IC50 of 58 nM in viability assay in T47D (PI3KαH1047R), with low potency against SKBR3 (PI3KαWT) cell lines.
PI3Kα H1047R inhibitor 17 (00 mg/kg, IP, qd) causes tumor regressions in the HCC1954 tumor model in mice.

物理化学性质&存储条件

分子量	364.45
分子式	C22H24N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-Methyl-2-morpholino-8-(1-(phenylamino)ethyl)-4H-chromen-4-one

参考文献

1. Ketcham JM, et al. J Med Chem. 2024 Mar 13. doi: 10.1021/acs.jmedchem.4c00078.