PI-701 | PI3KC2β inhibitor | Probechem Biochemicals

Chemical Structure : PI-701

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PI-701 (YM185453, PI 701)

货号: PC-23006Not For Human Use, Lab Use Only.

PI-701 (YM185453) is a selective inhibitor of class II PI3KC2β isoform with IC50 of 528 nM, does not display activity toward PI3K class I isoforms.

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生物&药学活性

PI-701 (YM185453) is a selective inhibitor of class II PI3KC2β isoform with IC50 of 528 nM, does not display activity toward PI3K class I isoforms.
PI-701 (YM185453) impaires proliferation of a panel of human cancer cell lines and primary cultures of acute myeloid leukemia (AML), glioblastoma multiforme (GBM), medulloblastoma (MB), neuroblastoma (NB), and small cell lung cancer (SCLC).
PI-701 (YM185453) induces apoptosis and sensitises cancer cells to chemotherapeutic agents.

物理化学性质&存储条件

分子量	553.64
分子式	C30H27N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-morpholino-2-(3-(naphthalene-2-sulfonamido)phenyl)quinazolin-6-yl)acetamide

参考文献

1. Boller D, et al. Anticancer Res. 2022 Jun;42(6):3217-3230.

PI-701 (YM185453, PI 701)

生物&药学活性

物理化学性质&存储条件

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PI-701 (YM185453, PI 701)

生物&药学活性

物理化学性质&存储条件

参考文献

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