PI-1840 | Proteasome inhibitor | Probechem Biochemicals

Chemical Structure : PI-1840

CAS No.: 1401223-22-0

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PI-1840 (PI1840)

货号: PC-42948Not For Human Use, Lab Use Only.

PI-1840 is a potent, selective, noncovalent, reversible inhibitor for proteasome chymotrypsin-like (CT-L) activity with IC50 of 27 nM, shows no effect on trypsin-like and peptidylglutamyl peptide hydrolyzing activities (IC50>100 uM).

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
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生物&药学活性

PI-1840 is a potent, selective, noncovalent, reversible inhibitor for proteasome chymotrypsin-like (CT-L) activity with IC50 of 27 nM, shows no effect on trypsin-like and peptidylglutamyl peptide hydrolyzing activities (IC50>100 uM).
PI-1840 also displays 100-fold more selectivity for the constitutive proteasome over the immunoproteasome.
PI-1840 induces the accumulation of proteasome substrates p27, Bax, and IκB-α, inhibits survival pathways and viability, and induces apoptosis in intact cancer cells, also sensitizes human cancer cells to the mdm2/p53 disruptor Nutlin.
PI-1840 suppresses the growth in nude mice of human breast tumor xenografts.

物理化学性质&存储条件

分子量	394.4668
分子式	C22H26N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetamide, N-(1-methylethyl)-2-(4-propylphenoxy)-N-[[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]methyl]-

参考文献

1. Kazi A, et al. J Biol Chem. 2014 Apr 25;289(17):11906-15.

2. Ozcan S, et al. J Med Chem. 2013 May 23;56(10):3783-805.

PI-1840 (PI1840)

生物&药学活性

物理化学性质&存储条件

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PI-1840 (PI1840)

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