PI-103 hydrochloride | PI3K/mTOR inhibitor | Probechem Biochemicals

Chemical Structure : PI-103 hydrochloride

CAS No.: 371935-79-4

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PI-103 hydrochloride (PI 103 hydrochloride, PI103 hydrochloride)

货号: PC-42329Not For Human Use, Lab Use Only.

PI-103 hydrochloride is a potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively.

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25 mg	￥2180	In stock
50 mg	￥3580	In stock
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生物&药学活性

PI-103 hydrochloride is a potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively.
PI-103 also inhibits TORC1 (>80% inhibition at 0.5 uM) and DNA-PK (IC50=14 nM), 15- to 20-fold less activity against class II PI3K C2β (IC50=43 nM), >1,300-fold selectivity over the class III PI3K Vsp34.
PI-103 potently inhibits proliferation and invasion of a wide variety of human cancer cells in vitro; shows activity in cancer xenograft models.

物理化学性质&存储条件

分子量	384.8163
分子式	C19H17ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 4.1 mg/mL; H2O: < 4 mg/mL
Chemical Name/SMILES	Phenol, 3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-, hydrochloride (1:1)

参考文献

1. Fan QW, et al. Cancer Cell. 2006 May;9(5):341-9.

2. Raynaud FI, et al. Cancer Res. 2007 Jun 15;67(12):5840-50.

3. Fan QW, et al. Cancer Res. 2007 Sep 1;67(17):7960-5.

4. Kojima K, et al. Leukemia. 2008 Sep;22(9):1728-36.

PI-103 hydrochloride (PI 103 hydrochloride, PI103 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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PI-103 hydrochloride (PI 103 hydrochloride, PI103 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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