PHY34 |CAS:2130033-55-3 Probechem Biochemicals

Chemical Structure : PHY34

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PHY34

货号: PC-35620Not For Human Use, Lab Use Only.

PHY34 is a potent autophagy inhibitor with cytotoxic effects by inhibiting autophagy at a late stage (MDA-MB-435 IC50=23 nM, MDA-MB-231 IC50=5.2 nM).

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生物&药学活性

PHY34 is a potent autophagy inhibitor with cytotoxic effects by inhibiting autophagy at a late stage (MDA-MB-435 IC50=23 nM, MDA-MB-231 IC50=5.2 nM).
PHY34 disrupts lysosomal function, significantly inhibits the growth of cancer cell lines in hollow fibers, as well as reduces ovarian tumor burden in a xenograft model.

物理化学性质&存储条件

分子量	522.506
分子式	C28H26O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	9-(benzo[d][1,3]dioxol-5-yl)-4-(((3aS,4R,6S,7R,7aR)-7-hydroxy-4-(hydroxymethyl)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-6-yl)oxy)naphtho[2,3-c]furan-1(3H)-one

参考文献

1. Young AN, et al. Mol Cancer Ther. 2018 Jul 17. pii: molcanther.1195.2017.

PHY34

生物&药学活性

物理化学性质&存储条件

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PHY34

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