PHTPP

Chemical Structure : PHTPP

CAS No.: 805239-56-9

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货号: PC-60267Not For Human Use, Lab Use Only.

PHTPP is a potent, selective antagonist of estrogen ERβ receptor, exhibits 36-fold selective for ERβ.

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25 mg	￥1380	In stock
50 mg	￥2280	In stock
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生物&药学活性

PHTPP is a potent, selective antagonist of estrogen ERβ receptor, exhibits 36-fold selective for ERβ.
PHTPP is fully effective as an ERα antagonist, while exhibiting no significant agonism on ERβ or Erα.
PHTPP enhances SKOV3 and OV2008 ovarian cancer cell growth in in vitro assays.

物理化学性质&存储条件

分子量	423.3
分子式	C20H11F6N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol

参考文献

1. Compton DR, et al. J Med Chem. 2004 Nov 18;47(24):5872-93.

2. Chan KK, et al. J Endocrinol. 2014 May 12;221(2):325-36.

3. Kajta M, et al. Neuroscience. 2013 May 15;238:345-60.

PHTPP

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PHTPP

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