PHT-427 |CAS:1191951-57-1 Probechem Biochemicals

Chemical Structure : PHT-427

CAS No.: 1191951-57-1

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PHT-427 (PHT 427;PHT427)

货号: PC-42878Not For Human Use, Lab Use Only.

PHT-427 (PHT427) is a small-molecule Akt inhibitor that binds selectively to the PH domain of AKT with Ki of 2.4 uM, inhibits phospho-Ser473-AKT in Panc-1 cells with IC50 of 6.3 uM.

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25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

PHT-427 (PHT427) is a small-molecule Akt inhibitor that binds selectively to the PH domain of AKT with Ki of 2.4 uM, inhibits phospho-Ser473-AKT in Panc-1 cells with IC50 of 6.3 uM.
PHT-427 decreases AKT activation and causes apoptosis at low micromolar concentrations in Panc-1 and MiaPaCa-2 pancreatic cancer cell lines.
PHT-427 inhibits AKT and its downstream targets in cells, exhibits good antitumor activity in pancreatic cancer cell xenografts in immunocompromised mice.

物理化学性质&存储条件

分子量	409.609
分子式	C20H31N3O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzenesulfonamide, 4-dodecyl-N-1,3,4-thiadiazol-2-yl-

参考文献

1. Moses SA, et al. Cancer Res. 2009 Jun 15;69(12):5073-81.

2. Meuillet EJ, et al. Mol Cancer Ther. 2010 Mar;9(3):706-17.

3. Dickinson SE, et al. Cancer Prev Res (Phila). 2016 Mar;9(3):215-24.

4. Kobes JE, et al. Pancreas. 2016 Sep;45(8):1158-66.

PHT-427 (PHT 427;PHT427)

生物&药学活性

物理化学性质&存储条件

参考文献

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PHT-427 (PHT 427;PHT427)

生物&药学活性

物理化学性质&存储条件

参考文献

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