PHD inhibitor IOX5 | HIF-PHD inhibitor | Probechem Biochemicals

Chemical Structure : PHD inhibitor IOX5

加入收藏

PHD inhibitor IOX5 (IOX5)

货号: PC-22353Not For Human Use, Lab Use Only.

IOX5 is a potent, selective HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 0.15 uM ((PHD2), does not inhibit other 2OG-dependent oxygenases (JMJD6, FIH, KDM6B etc.).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

IOX5 is a potent, selective HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 0.15 uM ((PHD2), does not inhibit other 2OG-dependent oxygenases (JMJD6, FIH, KDM6B etc.).
IOX5 shown to compete with 2OG for binding to PHD2, stabilizes HIF-1α at 0.5 μM in HEK293T cells.
IOX5 does not inhibit any of the other tested human 2OG-dependent oxygenases, including FIH and the histone-modifying 2OG oxygenases lysine-specific demethylase 4A (KDM4A), lysine-specific demethylase 5B (KDM5B), lysine-specific demethylase 6B (KDM6B), JMJD6 at 100 μM and the prolyl hydroxylase OGFOD1 at 50 uM.
stabilizes HIF-1α and substantially impacts AML growth and survival in vitro.
IOX5 compromises both MLL-rearranged and non-MLL AML in vivo, decreases AML engraftment and increases survival in vivo but does not affect normal hematopoiesis.
IOX5 compromises AML in a HIF-α dependent manner, requires the intact HIF system to exhibit its anti-leukemic activity.

物理化学性质&存储条件

分子量	368.36
分子式	C17H19F3N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-oxo-6-(1H-pyrazol-1-yl)-N-(((1r,4r)-4-(trifluoromethyl)cyclohexyl)methyl)-1,4-dihydropyridine-3-carboxamide

参考文献

1. Lawson H, et al. Nat Cancer. 2024 Apr 18. doi: 10.1038/s43018-024-00761-w.

PHD inhibitor IOX5 (IOX5)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PHD inhibitor IOX5 (IOX5)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.