PHA-408 |CAS:503555-55-3 Probechem Biochemicals

Chemical Structure : PHA-408

CAS No.: 503555-55-3

加入收藏

PHA-408 (PHA-767408;PHA767408;PHA 408)

货号: PC-61094Not For Human Use, Lab Use Only.

PHA-408 (PHA-767408) is a potent, highly selective, ATP-competitive IKK-2 inhibitor with IC50 of 40 nM, 350-fold selectivity over IKK-1.

规格	价格	库存
5 mg	￥3280	In stock
10 mg	￥5280	In stock
25 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

PHA-408 (PHA-767408) is a potent, highly selective, ATP-competitive IKK-2 inhibitor with IC50 of 40 nM, 350-fold selectivity over IKK-1.
PHA-408 inhibits LPS-induces TNF-α producton in PBMCs and HWB with IC50 of 20-30 nM, prevents IL-1β-induced IκBα phosphorylation in RASFs while sparing the JNK and p38 MAPK pathways and has no effect on IKK-2 phosphorylation.
PHA-408 demonstrates target-specific anti-inflammatory activities in in vivo model of airway inflammation.

物理化学性质&存储条件

分子量	560.03
分子式	C29H27ClFN7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-[[[5-Chloro-2-(4-methyl-1-piperazinyl)-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide

参考文献

1. Mbalaviele G, et al. J Pharmacol Exp Ther. 2009 Apr;329(1):14-25.

2. Sommers CD, et al. J Pharmacol Exp Ther. 2009 Aug;330(2):377-88.

3. Xie J, et al. Bioorg Med Chem. 2011 Feb 1;19(3):1242-55.

PHA-408 (PHA-767408;PHA767408;PHA 408)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PHA-408 (PHA-767408;PHA767408;PHA 408)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.