PGP inhibitor CP1

Chemical Structure : PGP inhibitor CP1

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货号: PC-49457Not For Human Use, Lab Use Only.

PGP inhibitor CP1 is a specific small-molecule phosphoglycolate phosphatase (PGP) inhibitor with IC50 of 0.39 uM (hPGP), blocks PGP-dependent glycolytic flux in mammalian cells.

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250 mg		Get quote

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生物&药学活性

PGP inhibitor CP1 is a specific small-molecule phosphoglycolate phosphatase (PGP) inhibitor with IC50 of 0.39 uM (hPGP), blocks PGP-dependent glycolytic flux in mammalian cells.
PGP inhibitor CP1 CP1 potently inhibited the activity of both human and murine PGP towards PG, also inhibited the activity of murine PGP towards the generic phosphatase substrate para-nitrophenylphosphate (pNPP).
PGP inhibitor CP1 also effectively inhibited the dephosphorylation of 2-phospho-L-lactate (2PL), 4-phosphoerythronate (4PE) and glycerol 3-phosphate (G3P).
PGP inhibitor CP1 interacted with the PGP cap domain (ITC Kd=0.78 uM), and bound to both the cap and the core domain of PGP.
PGP inhibitor CP1 displayed remarkable selectivity over 12 other mammalian haloacid dehalogenase (HAD) phosphatases (PP2B, PTP1B, intestinal alkaline phosphatase, etc.).
PGP inhibitor CP1 impairs glycolytic flux, impairs PGP-dependent cell proliferation, and induces PGP-dependent lipid droplet accumulation in HT1080 cells.
PGP inhibitor CP1 is a useful tool compound to probe the functional consequences of acute PGP inhibition, phenocopies effects of cellular PGP-deficiency.

物理化学性质&存储条件

分子量	496.475
分子式	C28H20N2O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2'-((4,4'-oxybis(benzoyl))bis(azanediyl))dibenzoic acid

参考文献

1. Elisabeth Jeanclos, et al. Nat Commun. 2022 Nov 11;13(1):6845.