PGMI-004A

Chemical Structure : PGMI-004A

CAS No.: 1313738-90-7

加入收藏

货号: PC-23304Not For Human Use, Lab Use Only.

PGMI-004A is a specific small molecule inhibitor of glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) with IC50 of 13.1 uM, Ki of 3.91 uM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

PGMI-004A is a specific small molecule inhibitor of glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) with IC50 of 13.1 uM, Ki of 3.91 uM.
PGMI-004A directly binds to the protein with KD of 9.4 uM.
PGMI-004A treatment results in decreased 2-PG and increased 3-PG levels in H1299 cells, which could be rescued by treatment with methyl-2-PG.
PGMI-004A treatment results in decreased oxidative PPP flux and NADPH/NADP+ ratio as well as reduced biosynthesis of lipids and RNA and cell proliferation in H1299 cells.
PGMI-004A treatment inhibits cancer cell proliferation and tumor growth, and alters 3-PG and 2-PG levels in primary leukemia cells from human patients, leading to attenuated leukemia cell proliferation.

物理化学性质&存储条件

分子量	463.38
分子式	C21H12F3NO6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,4-dihydroxy-9,10-dioxo-N-(4-(trifluoromethyl)phenyl)-9,10-dihydroanthracene-2-sulfonamide

参考文献

1. Hitosugi T, et al. Cancer Cell. 2012 Nov 13;22(5):585-600.

2. Wang P, et al. Bioorg Med Chem. 2018 May 1;26(8):1961-1970.

PGMI-004A

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PGMI-004A

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.