PGK1 activator L03 | PGK1 activator | Probechem Biochemicals

Chemical Structure : PGK1 activator L03

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PGK1 activator L03 (AT-051/43421517)

货号: PC-26835Not For Human Use, Lab Use Only.

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250 mg		Get quote

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生物&药学活性

PGK1 activator L03 (AT-051/43421517) is a specific small molecule activator of phosphoglycerate kinase 1 (PGK1) with SPR KD of 2.45 uM, significantly enhances enzymatic activity of PGK1 at 0.25-2 uM in AβO-induced SH-SY5Y cells.
L03 (AT-051/43421517) (1-2 uM) significantly increases the PGK1 activity of SH-SY5Y cells not exposed to AβO.
L03 (0.25 and 1 µM) significantly protected SH-SY5Y cells from the AβO-induced impairment of cell viability, L03 (0.25 and 1 µM) itself has no significant effect on the viability of SH-SY5Y cells.
L03 ameliorates AβO-damaged SH-SY5Y cells by promoting glycolysis, reduced apoptosis, enhanced glycolytic metabolism, restored TCA cycle, and decreased ROS production in AβO-damaged SH-SY5Y cells.
L03 (0.5 and 1 mg/kg, i.p.) improves the learning and memory ability in 3×Tg-AD mice.

物理化学性质&存储条件

分子量	304.39
分子式	C20H20N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-(2-(5-methoxyquinolin-4-yl)vinyl)-N,N-dimethylaniline

参考文献

1. Li M, et al. Alzheimers Res Ther. 2026 Mar 26;18(1):102.

PGK1 activator L03 (AT-051/43421517)

生物&药学活性

物理化学性质&存储条件

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PGK1 activator L03 (AT-051/43421517)

生物&药学活性

物理化学性质&存储条件

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