PG3 | p53 activator, ATF4 activator | Probechem Biochemicals

Chemical Structure : PG3

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PG3 (p53 activator, ATF4 activator PG3)

货号: PC-23283Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

PG3 is a small-molecule that restores p53 pathway-signaling in tumor cells with mutant-p53, activates ATF4 through ISR via kinase HRI (Heme-Regulated Inhibitor) and upregulates p53 target genes, inhibits cell viabiltiy of p53 mutation R273H (HT29 cell) with IC50 of 36 nM.
PG3 upregulates p21, PUMA, and DR5 in five cancer cell lines with various p53 mutational statuses through ATF4 (Activating Transcriptional Factor 4) and integrated stress response (ISR) independent of p53.
PG3 induces induce cell death via the HRI/ATF4/PUMA axis.

物理化学性质&存储条件

分子量	295.39
分子式	C18H21N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-5'-((4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)methylene)-4'-methoxy-1H,5'H-2,2'-bipyrrole

参考文献

1. Xiaobing Tian, et al. Oncotarget. 2024 Sep 17:15:614-633.

2. Tian X, et al. Neoplasia. 2021 Mar;23(3):304-325.

PG3 (p53 activator, ATF4 activator PG3)

生物&药学活性

物理化学性质&存储条件

参考文献

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PG3 (p53 activator, ATF4 activator PG3)

生物&药学活性

物理化学性质&存储条件

参考文献

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