PG3-Oc | p53 activator, ATF4 activator | Probechem Biochemicals

Chemical Structure : PG3-Oc

加入收藏

PG3-Oc (p53 activator, ATF4 activator PG3-Oc)

货号: PC-23284Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

PG3-Oc is a small-molecule that restores p53 pathway-signaling in tumor cells with mutant-p53, activates ATF4 and upregulates p53 target genes, inhibits cell viabiltiy of p53 mutation R273H (HT29 cell) with IC50 of 31 nM.
PG3-Oc inhibits cell proliferation and induces apoptosis in mutant p53-expressing cancer cell lines with IC50 values within the nano-molar range.
PG3-Oc has a 4- to 9-fold therapeutic index in colorectal cancer cell lines as compared to normal colon cells CCD 841 Con.
PG3-Oc treatment induces caspase-8 and caspase-3 activation in CRC cell lines, and caspase activation is required for PG3-Oc-induced cell death.
PG3-Oc partially restores the p53 pathway globally.
PUMA is required for PG3-Oc-mediated cell death, induces significant downregulation of MYC and upregulation of PUMA protein levels in a panel of p53 mutant cell lines, such as HT29, DLD1, FaDu, MDA-MB-231, and MDA-MB-468. SW480 and CAL27.
PG3-Oc induces upregulation of ATF4, ATF4 is a mediator of PG3-Oc-induced p53 pathway restoration.
PG3-Oc (5 mg/kg, times weekly for 2 wk) inhibits tumor growth in the HT29 mouse xenograft model.

物理化学性质&存储条件

分子量	451.61
分子式	C27H37N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	octyl (Z)-3-(5-((4'-methoxy-1H,5'H-[2,2'-bipyrrol]-5'-ylidene)methyl)-2,4-dimethyl-1H-pyrrol-3-yl)propanoate

参考文献

1. Xiaobing Tian, et al. Oncotarget. 2024 Sep 17:15:614-633.

2. Tian X, et al. Neoplasia. 2021 Mar;23(3):304-325.

PG3-Oc (p53 activator, ATF4 activator PG3-Oc)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PG3-Oc (p53 activator, ATF4 activator PG3-Oc)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.