PG-S3-001 |CAS:2047372-50-7 Probechem Biochemicals

Chemical Structure : PG-S3-001

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PG-S3-001 (STAT3 inhibitor)

货号: PC-63081Not For Human Use, Lab Use Only.

PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance.

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生物&药学活性

PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance.
PG-S3-001 shows no effect in a kinome screen (>100 cancer-relevant kinases).
PG-S3-001 inhibits phosphorylation of STAT3 at Y705, inhibits patient-derived pancreatic cancer cell proliferation in vitro and in vivo in the low micromolar range.
PG-S3-001 exhibits in vivo efficacy on pancreatic cancer xenografts.

物理化学性质&存储条件

分子量	652.677
分子式	C32H33F5N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-{(4-Cyclohexyl-benzyl)-[3-methyl-2-(methyl-pentafluorobenzenesulfonyl-amino)-butyryl]-amino}-benzoic acid

参考文献

1. Arpin CC, et al. Mol Cancer Ther. 2016 May;15(5):794-805.

PG-S3-001 (STAT3 inhibitor)

生物&药学活性

物理化学性质&存储条件

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PG-S3-001 (STAT3 inhibitor)

生物&药学活性

物理化学性质&存储条件

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