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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Liver X Receptor (LXR)-PFM046
PFM046

Chemical Structure : PFM046

CAS No.: 3053859-57-4

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PFM046 (PFM-046)

货号: PC-23680Not For Human Use, Lab Use Only.

PFM046 is a potent antagonist of liver X receptors (LXRs) with IC50 of 2.04 μM for LXRα and 1.58 μM for LXRβ.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PFM046 is a potent antagonist of liver X receptors (LXRs) with IC50 of 2.04 μM for LXRα and 1.58 μM for LXRβ.
PFM046 does not induce SREBP-1c activation and inhibited the activation of SCD1 and FASN.
PFM046 is able to significantly increase the expression of ABCA1 gene.
PFM046 shows a remarkable antitumor activity in two both in vitro-and in-vivo mouse models.

物理化学性质&存储条件

分子量 422.65
分子式 C29H42O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

22(S)-23-phenyl-24-norchol-5-en-3beta,22-diol

参考文献

1. Lorenzo Pontini, et al. Eur J Med Chem. 2025 Feb 5:283:117136.

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