PFKL activator NA-11 | CAS 2785323-65-9 Probechem Biochemicals

Chemical Structure : PFKL activator NA-11

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PFKL activator NA-11 (NA-11)

货号: PC-38283Not For Human Use, Lab Use Only.

PFKL activator NA-11 is a small-molecule, selective PFKL activator, inhibits the NOX2-dependent oxidative burst in neutrophils by activating the glycolytic enzyme phosphofructokinase-1 liver type (PFKL).

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生物&药学活性

PFKL activator NA-11 is a small-molecule, selective PFKL activator, inhibits the NOX2-dependent oxidative burst in neutrophils by activating the glycolytic enzyme phosphofructokinase-1 liver type (PFKL).
NA-11 binds to the AMP/ADP allosteric activation site, inhibits NOX2-dependent NETosis induced by PMA with IC50 of 4 nM.
NA-11 does not inhibit NETosis by directly modifying the enzymatic activity of NAMPT.
NA-11 relieved inhibition of PFKL by ATP (3.1 mM) with EC50 of 14 nM in in vitro kinase assays.
Neutrophils treated with NA-11 had reduced NOX2-dependent outputs, including neutrophil cell death (NETosis) and tissue damage.

物理化学性质&存储条件

分子量	401.466
分子式	C24H23N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-[2-(5-Hydroxy-1-pentyn-1-yl)phenyl]-4H,10H-pyrazolo[5,1-c][1,4]benzoxazepin-7-yl]acetamide

参考文献

1. Neri Amara, et al. Cell. 2021 Aug 19;184(17):4480-4494.e15.

PFKL activator NA-11 (NA-11)

生物&药学活性

物理化学性质&存储条件

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PFKL activator NA-11 (NA-11)

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物理化学性质&存储条件

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