PFKFB2 inhibitor B2

Chemical Structure : PFKFB2 inhibitor B2

加入收藏

货号: PC-23787Not For Human Use, Lab Use Only.

PFKFB2 inhibitor B2 is a small molecule inhibitor of PFKFB2 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2) with IC50 of 3.29 uM, inhibits PFKFB3 with IC50 of 11.89 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

PFKFB2 inhibitor B2 is a small molecule inhibitor of PFKFB2 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2) with IC50 of 3.29 uM, inhibits PFKFB3 with IC50 of 11.89 uM.
B2 inhibited cellular glycolysis and glycolytic capacity in A-498 cells, which express both PFKFB2 and PFKFB3.
B2 decreased fructose-1,6-bisphosphate and downstream glycolytic intermediates but increased fructose-6-phosphate levels, which is consistent with an inhibitory effect on PFK-1 activity.

物理化学性质&存储条件

分子量	239.31
分子式	C9H9N3OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((2-methoxyphenyl)amino)-1,3,4-thiadiazole-2-thiol

参考文献

1. Eyster C, et al. bioRxiv [Preprint]. 2024 Dec 25:2024.12.25.630325.